期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 24, 期 47, 页码 12250-12253出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201800872
关键词
albumin; anticancer drug; drug delivery; gold(I) complex; targeted therapeutics
资金
- EU [ED481B 2014/086-0]
- FCT Portugal (FCT Investigator)
- EPSRC
- EPSRC [EP/M003647/1] Funding Source: UKRI
Targeted delivery of potent cytotoxic drugs to cancer cells minimizes systemic toxicity and several side effects. NHC*-Au-Cl has already been proven to be a potent anticancer agent. In this study, we explore a strategy based on chemoselective cysteine conjugation of NHC*-Au-Cl to albumin and trastuzumab (Thiomab LC-V205C) to potentiate drug-ligand ratio, pharmacokinetics, as well as drug efficacy and safety. This strategy is a step forward towards the use of gold-based anticancer agents as targeted therapies.
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