期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 24, 期 14, 页码 3434-3438出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201800105
关键词
C-H activation; N-heterocycle; olefination; palladium; remote
资金
- Scripps Research Institute
- U.S. NSF [CHE-1465292]
- Direct For Mathematical & Physical Scien [1465292] Funding Source: National Science Foundation
A single and simple ortho-sulfonyl benzonitrile template was developed to achieve remote C-H olefination of six different classes of N-heterocycles. We demonstrate that, by varying precatalysts and conditions, the same template can be applied to the remote C-H activation of six structurally distinct heterocyclic scaffolds, and the site-selectivity can be predicted based on distance and geometry. Furthermore, this new development shows that template-directed remote C-H activation is possible through macrocyclopalladation processes with smaller ring sizes.
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