期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 24, 期 49, 页码 12890-12901出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201801085
关键词
black phosphorus; cancer; magnetofluorescence; photothermal therapy; quantum dots
资金
- Jiangsu province science and technology support plan [BE2015367]
- Jiangsu Higher Education Institutions
- Jiangsu Collaborative Innovation Center of Biomedical Functional Materials
Combination therapies for tumors based on different therapeutic approaches should try to improve treatment efficacy, but also to reduce side-effects related to the exogenous stimulus and premature release. In the following study, we established and validated a pH/near-infrared (NIR)/glutathione (GSH)/-responsive multifunctional disulfide cross-linked Fe3O4@C nanocarriers (ss-Fe3O4@C NCs) with black phosphorus quantum dots (BPQDs) as a capping agent. BPQDs and carbon shell of Fe3O4@C nanoparticles (NPs) were used as a photothermal agents, while the inner empty nucleus that allows for a high drug payload served as an effective drug carrier. These magnetofluorescent BPQDs@DOX@ss-Fe3O4@C NPs were conjugated with a targeting aptamer (epidermal growth factor receptor: EGFR), denoted as BPQDs@DOX@ss-Fe3O4@C-EGFR NPs, for targeting dual modal magnetic resonance (MR)/fluorescence imaging. The synthetic NCs showed that drug release was dependent on pH, near-infrared (NIR), and intracellular GSH levels, with minimum systemic release in the blood and maximum drug release within the tumors. Also, the photothermal effect resulting from the Fe3O4@C NPs and BPQDs upon application to NIR light caused a rapid rise in local temperature, which accounted for the highest enhancement of cell cytotoxicity. Thus, a theranostic system consisting of BPQDs@DOX@ss-Fe3O4@C-EGFR NPs is shown to generate excellent advantages in combined chemotherapy/photothermal therapy (PTT) with minimal side effects.
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