Three-component hetero-domino cyclization and copper-catalyzed double A3-coupling reaction of ethane-1,2-diamines, formaldehyde, and alkynes to afford 1,3-dipropargylimidazolidines

A novel and efficient approach to the synthesis of 1,3-dipropargylimidazolidines via a hetero-domino cyclization and copper-catalyzed double A(3)-coupling reaction of ethane-1,2-diamines, formaldehyde, and alkynes has been reported. The transformation provides a useful method for the synthesis of imidazolidine derivatives.