Non-covalent Coating of Liposome Surface with IgG through Its Constant Region

Here we present a liposome non-covalently coated with immunoglobulin G (IgG) by using a peptide ligand to the constant region of IgG. IgG coated on the liposome still maintained binding ability to a complementary antigen protein but it was not recognized by Fc gamma receptors (Fc gamma Rs) of monocytes. The stealth feature of the IgG-coated liposome may be useful to avoid clearance by macrophages in vivo to extend the blood half-life of the liposome.