期刊
CHEMISTRY CENTRAL JOURNAL
卷 12, 期 -, 页码 -出版社
SPRINGEROPEN
DOI: 10.1186/s13065-018-0441-2
关键词
DprE1; Antitubercular agents; Covalent and non covalent inhibitors; Future needs
Tuberculosis has proved harmful to the entire history of mankind from past several decades. Decaprenyl-phosphorylribose 2'-epimerase (DprE1) is a recent target which was identified in 2009 but unfortunately it is neither explored nor crossed phase II. In past several decades few targets were identified for effective antitubercular drug discovery. Resistance is the major problem for effective antitubercular drug discovery. Arabinose is constituent of mycobacterium cell wall. Biosynthesis of arabinose is FAD dependant two step epimerisation reaction which is catalysed by DprE1 and DprE2 flavoprotein enzymes. The current review is mainly emphases on DprE1 as a perspective challenge for further research.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据