期刊
CHEMISTRY & BIODIVERSITY
卷 15, 期 4, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201700550
关键词
indole diketopiperazine alkaloids; Aspergillus ochraceus; asperochramides A-D; X-ray diffraction; ECD calculation
资金
- Ministry of Education of the People's Republic of China [T2016088]
- National Natural Science Foundation [81725021]
- Innovative Research Groups of the National Natural Science Foundation of China [81721005]
- National Natural Science Foundation of China [31700298]
- Academic Frontier Youth Team of HUST
- Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College (HUST)
Asperochramides A-D (1-4), a new natural product and three new indole diketopiperazine alkaloids, along with seven known analogs (5-11), were isolated from the ethyl acetate extract of Aspergillus ochraceus. Their structures were elucidated by extensive spectroscopic analyses, ECD calculation, and single-crystal X-ray diffraction analysis. Compounds 3 and 4 represent a rare group of indole diketopiperazine alkaloid with a 3-hydroxyl-2-indolone moiety. The invitro anti-inflammatory effects of compounds 1 and 3-11 were investigated by using LPS-stimulated murine macrophage RAW 264.7 cells. Compounds 1, 8, 10, and 11 showed potential anti-inflammatory activities.
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