期刊
CHEMICO-BIOLOGICAL INTERACTIONS
卷 281, 期 -, 页码 121-136出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2017.12.024
关键词
Rheumatoid arthritis; Oxidative stress; Antioxidants; Cellular signaling
资金
- National Research Foundation of Korea - Ministry of Education [2017-R1D1A3B03033401]
There are numerous extra- and intra-cellular processes involved in the production of reactive oxygen species (ROS). Augmented ROS generation can cause the damage of biomolecules such as proteins, nucleic acid and lipids. ROS act as an intracellular signaling component and is associated with various inflammatory responses, chronic arthropathies, including rheumatoid arthritis (RA). It is well documented that ROS can activate different signaling pathways having a vital importance in the patho-physiology of RA. Hence, understanding of the molecular pathways and their interaction might be advantageous in the development of novel therapeutic approaches for RA.
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