期刊
CHEMICAL SOCIETY REVIEWS
卷 47, 期 11, 页码 3770-3787出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cs00610a
关键词
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资金
- Australian Research Council Discovery Early Career Researcher Award [DE180100194]
- Australian Research Council Discovery Project [DP170100036]
- Parkinson's Victoria PhD Scholarship
- Australian National Health and Medical Research Council Industry Career Development Fellowship [1122981]
- Agilent Technologies
Chemical imaging provides new insight into the fundamental atomic, molecular, and biochemical composition of tissue and how they are interrelated in normal physiology. Visualising and quantifying products of pathogenic reactions long before structural changes become apparent also adds a new dimension to understanding disease pathogenesis. While chemical imaging in isolation is somewhat limited by the nature of information it can provide (e.g. peptides, metals, lipids, or functional groups), integrating immunohistochemistry allows simultaneous, targeted imaging of biomolecules while also mapping tissue composition. Together, this approach can provide invaluable information on the inner workings of the cell and the molecular basis of diseases.
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