期刊
CHEMICAL REVIEWS
卷 118, 期 21, 页码 10748-10773出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.7b00723
关键词
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资金
- National Institutes of Health Nanomedicine Center for the Optical Control of Biological Function [2PN2EY018241]
- National Science Foundation Major Research Instrumentation Award [1041078]
- EAGER award [IOS-1451027]
- National Eye Institute [EY018957, P30 EY003176]
- Thome Foundation for Biomedical Research
- Foundation Fighting Blindness
- [S10 RR028971]
- NATIONAL EYE INSTITUTE [P30EY003176, R01EY024334] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS100911] Funding Source: NIH RePORTER
Degenerative retinal diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD) affect millions of people around the world and lead to irreversible vision loss if left untreated. A number of therapeutic strategies have been developed over the years to treat these diseases or restore vision to already blind patients. In this Review, we describe the development and translational application of light-sensitive chemical photoswitches to restore visual function to the blind retina and compare the translational potential of photoswitches with other vision-restoring therapies. This therapeutic strategy is enabled by an efficient fusion of chemical synthesis, chemical biology, and molecular biology and is broadly applicable to other biological systems. We hope this Review will be of interest to chemists as well as neuroscientists and clinicians.
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