期刊
CHEMICAL RECORD
卷 18, 期 9, 页码 1314-1340出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/tcr.201700098
关键词
Cyclization; Cross-coupling; Dicarbofunctionalization; Heck carbometallation; Olefins
资金
- University of New Mexico (UNM)
- National Science Foundation [NSF CHE-1554299]
Transition metal (TM)-catalyzed difunctionalization of unactivated olefins with two carbon-based entities is a powerful method to construct complex molecular architectures rapidly from simple and readily available feedstock chemicals. While dicarbofunctionalization of unactivated olefins has a long history typically with the use of either carbon monoxide to intercept C(sp(3))-[M] (alkyl-TM) species or substrates lacking in -hydrogen (-Hs), development of this class of reaction still remains seriously limited due to complications of -H elimination arising from the insitu-generated C(sp(3))-[M] intermediates. Over the years, different approaches have been harnessed to suppress -H elimination, which have led to the development of various types of olefin dicarbofunctionalization reactions even in substrates that generate C(sp(3))-[M] intermediates bearing -Hs with a wide range of electrophiles and nucleophiles. In this review, these developments will be discussed both through the lens of historical perspectives as well as the strategies scrutinized over the years to address the issue of -H elimination. However, this review article by no means is designed to be exhaustive in the field, and is merely presented to provide the readers an overview of the key reaction developments.
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