期刊
TOXICOLOGY MECHANISMS AND METHODS
卷 25, 期 6, 页码 433-439出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/15376516.2015.1070229
关键词
Cytotoxicity; DNA damage; mesoporous silica nanoparticles; nanotoxicity; reactive oxygen species
类别
资金
- Mashhad University of Medical Sciences, Mashhad, Iran
In the recent years, the use of mesoporous silica nanoparticles (MSNs) has been extended in biomedical fields such as cancer therapy, drug and gene delivery, biosensors, and enzyme immobilization. Although nanomaterials are currently being widely used in modern technology, there is a lack of information regarding to the health and environmental implications of manufactured nanomaterials. In the present study, the effects of MSNs and surface functionalized MSNs on cell viability, markers of oxidative damages (mainly intracellular reactive oxygen species (ROS) formation), and oxidative DNA damage were investigated in vitro in rat pheochromocytoma PC12 cells. Following exposure of these nanoparticles (1.95-1000 mu g/mL) to PC12 cells for 12 and 24h, no significant reduction of cell viability was observed compared with control. Moreover, ROS formation and oxidative DNA damage were not significantly changed by these nanoparticles even at high concentrations or prolong exposures. In conclusion, the results showed that neither MSNs nor functionalized MSNs exhibited any remarkable in vitro toxic properties in PC12 cells even at high concentration.
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