期刊
CHEMICAL PHYSICS LETTERS
卷 706, 期 -, 页码 285-294出版社
ELSEVIER
DOI: 10.1016/j.cplett.2018.06.015
关键词
Bone morphogenetic protein-2; Gold; Molecular dynamics; Protein adsorption; Silicon nitride
资金
- US National Science Foundation (NSF CMMI: Award) [1663128]
- CNPq (National Council for Scientific and Technological Development Brazil)
Adsorption of BMP-2 on hydrophobic gold and hydrophilic silicon nitride is studied using molecular dynamics simulations. The wetting behavior of the dissolution media directly guided the protein-substrate interaction, impacting the protein adsorption. The saline solution restricted the movement of the protein on gold, limiting adsorption to hydrophobic and charged residues while preserving the secondary structure. Stronger adsorption occurred on silicon nitride where the protein had more flexibility to interact with the surface leading to the disruption of beta-sheet structures in two orientations. This research contributes to the understanding of BMP-2 adsorption behavior in four orthogonal orientations with medically relevant materials. (C) 2018 Elsevier B.V. All rights reserved.
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