期刊
CHEMICAL ENGINEERING JOURNAL
卷 351, 期 -, 页码 548-558出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2018.06.100
关键词
MoS2 nanoparticles; Bottom-up; Drug loading; Photothermal therapy; Chemotherapy
资金
- National Natural Science Foundation of China [51702214, 81670485]
- Shanghai Sailing Program - Shanghai Committee of Science and Technology [17YF1412600]
- Chenguang Program - Shanghai Education Development Foundation and Shanghai Municipal Education Commission [15CG52]
The bottom-up approach can be used to synthesize MoS2 nanosheets with controlled morphology and synchronous surface modification. However, these MoS2 nanosheets frequently stacked with each other to form a mull-layer structure, which greatly affects the improvement of their drug loading capacity. In this work, we reported a facile bottom-up synthesis of polyvinyl pyrrolidone (PVP) coated biocompatible MoS2 nanoparticles (NPs) with admirable drug loading capacity for synergistic tumor photothermal and chemotherapy. The colloidal-stable MoS2 NPs possessed excellent photothermal transducing performance with the photothermal conversion efficiency of 37.5%. Further, the porous structure of MoS2 NPs facilitated the drug payload with a tunable drug loading percentage of 7%-72%. More importantly, the drug release from the MoS2 NPs followed a controlled pH- and NIR-dual modal responsive manner. The material design takes account of the drug loading capacity of NPs and the photothermal feature of MoS2, providing a paradigm that the research of cancer therapy agents can be moved forward by integrating the advantages of different nanomaterials into one dosage.
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