期刊
CHEMICAL ENGINEERING JOURNAL
卷 336, 期 -, 页码 741-747出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2017.11.179
关键词
Competing reactions; Fast coupling reaction; Diblock copolymer; Reaction kinetics; Reactive jet mixing; CIJ mixer
资金
- National Natural Science Foundation of China [21544005]
- Natural Science Foundation of Jiangsu Higher Education Institutions of China [15KJB430034]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- National Science Foundation under MRSEC Program [DMR-0212302]
- NIRT Program [CTS-0506966]
- IPRIME at the University of Minnesota
This work studies the fast coupling reaction of polymers with a water competition under confined impinging jet (CIJ) mixing. The coupling reaction between polystyrene acyl chloride (PS-COCl) and polyethylene glycol amine (PEG-NH2) is used either with or without a water competition. The reactions are implemented either in a molecular homogeneous and perfect mixing or in a CIJ mixing reactor. The simulations reveal that although the process with Re-j = 1770 is mixing limited (tau(rxn1) (similar to 1.8 ms) < tau(rxn2) (similar to 7.4 ms) < tau(mix) (similar to 8.5 ms)), the desired coupling conversion (16%) and selectivity (0.17) is approaching to 18% and 0.19 respectively, which were their maxima occurred in a molecular homogeneous and perfect mixing. The simulation results successfully rationalize the low coupling conversion of about 17% reported in a previous experiment. Moreover, this study provides guidance to improve the desired conversion by increasing either [PEG-NH2](0)/[PS-COCl](0) or k(2)/k(1), which is crucial for the in-situ reactive flash nanoprecipitation (RFNP) to generate stable nanoparticles, especially with a higher drug load and less reactive polymers. The successful acquisition of the time scales of the competing reactions and mixing would be beneficial to revealing the mechanism and process of particle formation and evolution in the RFNP, where time scales of chemical reactions, mixing, and precipitation would compete to each other.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据