Gas-stimuli-responsive molecularly imprinted polymer particles with switchable affinity for target protein

Gas-responsive molecularly imprinted polymer (MIP) particles, which have nanocavities in their shell layer for protein recognition, were developed for the first time. The MIP particles showed higher affinity for the target protein inside a CO2-treated aqueous medium as compared to that under N-2-treated conditions, while retaining selectivity to the target protein.