期刊
CHEMICAL COMMUNICATIONS
卷 54, 期 44, 页码 5550-5553出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc01726c
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资金
- CNRS
- Ministere de l'enseignement superieur et de la recherche
- French National Research Agency (ANR) [ANR-15-CE07-0009-01]
- Agence Nationale de la Recherche (ANR) [ANR-15-CE07-0009] Funding Source: Agence Nationale de la Recherche (ANR)
An arabinofuranosylhydrolase from the GH51 family was transformed into an acyl transferase by mutation of the catalytic acid/base amino acid. The resulting enzyme was able to transfer carboxylic acid onto the anomeric position of arabinose with complete chemo-and stereoselectivity. A wide range of acyl alpha-L-arabinofuranoses was obtained with yields ranging from 25 to 83%. Using this method, ibuprofen and N-Boc phenylalanine were successfully transformed into their corresponding acyl conjugates, expanding the scope of the reaction to drugs and amino acids.
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