期刊
CHEMICAL COMMUNICATIONS
卷 54, 期 9, 页码 1057-1060出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc08222c
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资金
- JSPS KAKENHI [17K01399, 26750162]
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
Stellated fibrous mesoporous silica nanospheres significantly improve the cellular uptake of cancer antigen and the maturation of bone marrow derived dendritic cells in vitro. Moreover, the combination of poly(I:C) with stellated fibrous MS nanospheres markedly decreases the necessary dose of poly(I:C) for anti-tumor immunity, and thus opens new opportunities for the future clinical application of poly(I:C) in cancer immunotherapy.
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