期刊
CHEMICAL COMMUNICATIONS
卷 54, 期 5, 页码 539-542出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc07812a
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资金
- MHRD, New Delhi
- SERB
- SERB-DST, New Delhi, Govt. of India [EMR/2016/001113]
- IIT Indore
The morphological alteration of lysosomes is a powerful indicator of various pathological disorders. In this regard, we have designed and synthesized a new water soluble fluorescent Schiff-base ligand (L-lyso) containing two hydroxyl groups. L-lyso exhibits excellent two-photon properties with tracking of lysosomes in live cells as well as in 3D tumor spheroids. Furthermore, it can label lysosomes for more than 3 days. Thus, L-lyso has an edge over the commercially available expensive LysoTracker probes and also over other reported probes in terms of its long-term imaging, water solubility and facile synthesis.
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