4.7 Article

Identification of a rhodium(III) complex as a Wee1 inhibitor against TP53-mutated triple-negative breast cancer cells

期刊

CHEMICAL COMMUNICATIONS
卷 54, 期 20, 页码 2463-2466

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc09384e

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资金

  1. Hong Kong Baptist University [FRG2/16-17/007]
  2. Health and Medical Research Fund [HMRF/14130522, HMRF/14150561]
  3. Research Grants Council [HKBU/12301115, HKBU/201913]
  4. National Natural Science Foundation of China [21575121, 21628502]
  5. Guangdong Province Natural Science Foundation [2015A030313816]
  6. Hong Kong Baptist University
  7. Interdisciplinary Research Matching Scheme [RC-IRMS/15-16/03]
  8. Innovation and Technology Fund [ITS/260/16FX]
  9. Collaborative Research Fund [C5026-16G]
  10. Matching Proof of Concept Fund [MPCF-001-2017/18]
  11. Science and Technology Development Fund, Macao SAR [098/2014/A2]
  12. University of Macau [MYRG2015-00137-ICMS-QRCM, MYRG2016-00151-ICMS-QRCM]

向作者/读者索取更多资源

The rhodium(III) complex 1 was identified as a potent Wee1 inhibitor in vitro and in cellulo. It decreased Wee1 activity and unscheduled mitotic entry, and induced cell damage and death in TP53-mutated triple-negative breast cancer cells. 1 represents a promising scaffold for further development of more potent metal-based Wee1 antagonists.

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