期刊
CHEMICAL COMMUNICATIONS
卷 54, 期 15, 页码 1897-1900出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc07048a
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资金
- Inserm
- CNRS
- MNHN
Here, we report on the in vitro binding properties of the known pyridine dicarboxamide G-quadruplex ligand 360A and a new dimeric analogue (360A)(2A) to human telomeric DNA higher-order G-quadruplex (G4) structures. This study points to original binding features never reported for G4 ligands, and reveals a greater efficiency for the dimeric ligand to displace RPA (a ssDNA binding protein involved in telomere replication) from telomeric DNA.
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