期刊
CHEMICAL COMMUNICATIONS
卷 54, 期 13, 页码 1627-1630出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc09872c
关键词
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资金
- Gobierno Vasco [IT_1033-16]
- MINECO [CTQ2016-78395-P, RYC-2012-09873]
- Cost-CHAOS action [CA15106]
An efficient ligand-free Fe-catalyzed oxidative Ugi-type reaction toward the assembly of alpha-amino amides and short peptides is described. The reaction proceeds through the alpha-C(sp(3))-H oxidation of N, N-dimethylanilines and further nucleophilic attack of the resulting iminium species by isocyanides. Additive screening showed that judicious choice of the carboxylic acid could lead to the formation of alpha-amino imides via a 3-component reaction. The process occurs with operational simplicity and is compatible with a variety of sensitive functional groups.
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