期刊
CHEMICAL COMMUNICATIONS
卷 54, 期 21, 页码 2599-2602出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc09129j
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资金
- NIH [P30 CA08748]
- National Institutes of Health [R00 CA1440138]
- Thompson grant
- Francois Wallace Monahan Fellowship from the JLM Benevolent Fund
The inverse electron-demand Diels-Alder reaction between tetra-zine (Tz) and trans-cyclooctene (TCO) facilitates the efficient radio-synthesis of Ac-225-labelled radioimmunoconjugates in a two-step method, outperforming conventional approaches based on isothio-cyanate couplings.
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