期刊
CHEMICAL COMMUNICATIONS
卷 54, 期 6, 页码 654-657出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc09491d
关键词
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资金
- AbbVie [1097737]
- Bayer [1097737]
- Boehringer Ingelheim [1097737]
- Canada Foundation for Innovation [1097737]
- Canadian Institutes for Health Research [1097737]
- Genome Canada [1097737]
- GlaxoSmithKline [1097737]
- Janssen [1097737]
- Lilly Canada [1097737]
- Novartis Research Foundation [1097737]
- Ontario Ministry of Economic Development and Innovation [1097737]
- Pfizer [1097737]
- Takeda [1097737]
- Wellcome Trust [1097737, 092809/Z/10/Z]
- MMU
A mild calcium catalysed Beckmann rearrangement has been realised, which forgoes the more traditional harsh reactions conditions associated with the transformation. The catalyst system is shown to be tolerant towards a wide variety of functional groups relevant to natural product synthesis and medicinal chemistry and the synthetic utility of the reaction has also been investigated. A preliminary mechanistic investigation was performed to understand the nature of the incoming nucleophile and a possible reaction pathway is described.
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