期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 66, 期 1, 页码 21-28出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c17-00222
关键词
deuterium labeling; heterogeneous catalyst; deuterium oxide; hydrogen; dehydrogenation
资金
- Research Foundation for Pharmaceutical Sciences
- Japan Society for the Promotion of Science [15J01556, 16K15100]
- Grants-in-Aid for Scientific Research [16K08169, 15J01556, 16K15100] Funding Source: KAKEN
Deuterium-labeled compounds are widely utilized in various scientific fields. We summarize the recent advances in the direct deuteration of sugar, saturated fatty acid, and arene derivatives using heterogeneous platinum group metal on carbon catalysts by our research group. Hydrogen gas is a key catalyst-activator to facilitate the present H-D exchange reactions. In this review, the direct activation method of catalysts using in situ-generated hydrogen based on the dehydrogenation of alcohols is introduced. The obtained multiple deuterium-labeled products, including bioactive compounds, are expected to contribute to the development of many scientific investigations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据