期刊
CHEMBIOCHEM
卷 19, 期 15, 页码 1574-1589出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201800182
关键词
cell imaging; cell organelles; iridium; photodynamic therapy; photosensitizers
资金
- MRC [G0701062]
- EPSRC [EP/G006792]
- Royal Society
Photodynamic therapy (PDT) is a noninvasive treatment for certain types of cancer, bacterial, fungal and viral infections, and skin diseases. In recent years, adaptation of this treatment so as to achieve more specific targeted cancer therapy in particular has attracted significant attention. We focus herein on the design of novel iridium-based photosensitizers (PSs) with tunable photophysical and photobiological properties as efficient PDT agents. We highlight the ability of some Ir-III photosensitizers to target specific cellular components, including their activation by one- and two-photon irradiation.
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