期刊
CEREBRAL CORTEX
卷 28, 期 7, 页码 2594-2609出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhy084
关键词
axon initial segment; burst firing; Cav3.2; dentate gyrus; hippocampus; intrinsic excitability; mature granule cells; T-type calcium channels
资金
- Deutsche Forschungsgemeinschaft (DFG) [Kr1879 / 5-1, Kr1879 / 6-1, SFB779 TPB8, TPB14]
- DIP grant
- Equipe FRM [15/ANR-15-CE16]
- WGL
- LSA research group Molecular Physiology [MK-IfN-2009-01]
Mature granule cells are poorly excitable neurons that were recently shown to fire action potentials, preferentially in bursts. It is believed that the particularly pronounced short-term facilitation of mossy fiber synapses makes granule cell bursting a very effective means of properly transferring information to CA3. However, the mechanism underlying the unique bursting behavior of mature granule cells is currently unknown. Here, we show that Cav3.2 T-type channels at the axon initial segment are responsible for burst firing of mature granule cells in rats and mice. Accordingly, Cav3.2 knockout mice fire tonic spikes and exhibit impaired bursting, synaptic plasticity and dentate-to-CA3 communication. The data show that Cav3.2 channels are strong modulators of bursting and can be considered a critical molecular switch that enables effective information transfer from mature granule cells to the CA3 pyramids.
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