期刊
CEREBRAL CORTEX
卷 29, 期 4, 页码 1607-1618出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhy059
关键词
anti-correlation; default mode network; fMRI; GABA; glutamate
资金
- NARSAD [MH114020, MH094594, MH104449]
- Intramural Research Program of the National Institute on Drug Abuse of the National Institutes of Health
- NATIONAL INSTITUTE ON DRUG ABUSE [ZIADA000469] Funding Source: NIH RePORTER
Coordinated activity within and differential activity between large-scale neuronal networks such as the default mode network (DMN) and the control network (CN) is a critical feature of brain organization. The CN usually exhibits activations in response to cognitive tasks while the DMN shows deactivations; in addition, activity between the two networks is anti-correlated at rest. To address this issue, we used functional MRI to measure whole-brain BOLD signal during resting-state and task-evoked conditions, and MR spectroscopy (MRS) to quantify GABA and glutamate concentrations, in nodes within the DMN and CN (MPFC and DLPFC, respectively) in 19 healthy individuals at 3 Tesla. We found that GABA concentrations in the MPFC were significantly associated with DMN deactivation during a working memory task and with anti-correlation between DMN and CN at rest and during task performance, while GABA concentrations in the DLPFC weakly modulated DMN-CN anti-correlation in the opposite direction. Highlighting specificity, glutamate played a less significant role related to brain activity. These findings indicate that GABA in the MPFC is potentially involved in orchestrating between-network brain activity at rest and during task performance.
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