期刊
CEREBRAL CORTEX
卷 29, 期 4, 页码 1670-1681出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhy065
关键词
biophysical modeling; cognitive capacity; prefrontal cortex; synchrony; working memory
资金
- National Institutes of Mental Health [NIMH R37MH087027, NIMH R01MH091174]
- Picower Institute Innovation Fund
There is a severe limitation in the number of items that can be held in working memory. However, the neurophysiological limits remain unknown. We asked whether the capacity limit might be explained by differences in neuronal coupling. We developed a theoretical model based on Predictive Coding and used it to analyze Cross Spectral Density data from the prefrontal cortex (PFC), frontal eye fields (FEF), and lateral intraparietal area (LIP). Monkeys performed a change detection task. The number of objects that had to be remembered (memory load) was varied (1-3 objects in the same visual hemifield). Changes in memory load changed the connectivity in the PFC-FEF-LIP network. Feedback (top-down) coupling broke down when the number of objects exceeded cognitive capacity. Thus, impaired behavioral performance coincided with a break-down of Prediction signals. This provides new insights into the neuronal underpinnings of cognitive capacity and how coupling in a distributed working memory network is affected by memory load.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据