Solubility and thermodynamic functions of cefazolin acid in pure and mixed solvents at (278.15-30815)K

Solvent screening is of great importance in the design and optimization of drug crystallization. In this paper, the solubility data of cefazolin acid in five pure solvents and one binary solvent mixtures (N, N-dimethylformamide + 2-propanol) were experimentally measured in temperature range from (278.15-308.15) K by using UV spectrometer method. The melting temperature of cefazolin acid was estimated by three-level group contribution method. All the experimental solubility data were correlated by the modified Apelblat model and the lambda h equation. The experimental solubility data in binary solvent mixtures were also correlated by the nearly ideal binary solvent CNIBS/Redlich-Kister model. In addition, based on the modified van't Hoff equation, the thermodynamic properties of cefazolin acid dissolution process were also calculated and discussed. (C) 2014 Elsevier B.V. All rights reserved.