Measurement and correlation of solubility and dissolution properties of flunixin meglumine in pure and binary solvents

The solubility of flunixin meglumine (FM) in six pure solvents and binary solvents of ethanol + isopropanol was measured over the temperature ranged from 28315 K to 328.15 K by using a static gravimetric method. It is positively correlated with temperature and negatively correlated with the molar fraction of isopropanol. The modified Apelblat equation was used to correlate the experimental solubility in pure solvents. Dissolution properties based on the modified Apelblat equation were calculated and discussed. The solubility in binary solvents at various temperatures was well correlated by the nearly ideal binary solvent (NIBS)/Redlich-Kister model. In addition, in order to correlate the solubility to both the composition and temperature in mixed solvents, a new model related to dielectric constant was proposed. (C) 2015 Elsevier B.V. All rights reserved.