期刊
OCL-OILSEEDS AND FATS CROPS AND LIPIDS
卷 22, 期 4, 页码 -出版社
EDP SCIENCES S A
DOI: 10.1051/ocl/2015003
关键词
White adipocyte; brite; brown adipocyte; arachidonic acid; prostaglandin; obesity
类别
White adipocytes are storing energy under the form of triglycerides whereas brown adipocytes dissipate energy from triglycerides by producing heat. In rodents and possibly in humans both types of fat cells participate in the total energy balance. From a quantitative view point, a positive energy balance (energy intake > energy expenditure) is commonly regarded as a major factor contributing to obesity. Recent studies demonstrate that by altering rates of adipocyte differentiation and proliferation, differences in fatty acid composition of dietary fats may also contribute to adipose tissue development, in particular with respect to the relative intake of omega 6 to omega 3 poly-unsaturated fatty acids (PUFAs). The omega 6/omega 3 ratio determines the availability of omega 6-arachidonic acid (ARA) within adipose tissue and thus the level of various prostaglandins derived from the cyclooxygenase-mediated pathway. We had shown earlier that prostacyclin (Prostaglandin I2) stimulates fat cell differentiation and this effect could be reversed by omega 3-PUFA supplementation. Moreover, we had assessed that under conditions of genome stability a Western-like fat diet rich in omega 6-PUFA was sufficient to induce a gradual fat mass enhancement across generations. Recently, we have characterized a second effect of some ARA metabolites (prostaglandins E2 and F2 alpha) which appear to inhibit the formation of brown adipocytes within white adipose tissue. Altogether, our results demonstrate that, in addition to favoring white adipose tissue formation, dietary excess of omega 6-PUFA prevents the browning process to take place in white adipose tissue depots, and strongly suggest a favorable role of omega 3-PUFA supplementation in preventing both processes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据