期刊
CERAMICS INTERNATIONAL
卷 44, 期 8, 页码 9472-9478出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceramint.2018.02.164
关键词
Ceramic nanocomposite; Alumina; Zirconia; Laser patterning; Osseous differentiation; Cellular arrangement
资金
- Spanish Ministry of Science and Innovation (MICINN) [MAT2012-38645]
- Principality of Asturias [GRUPIN 14-109]
- JAE-PREDOC program (CSIC)
Customized square grid arrangements of different groove depths (1.0, 1.5 and 3.0 gm) and separations (10 and 30 pm) were successfully laser patterned, using a nanosecond pulsed fibre laser, on the surface of 10 mol% ceriastabilized zirconia and alumina (10CeTZP-Al2O3) nanocomposite discs (diameter: 10 mm; thickness: 1.5 mm). The patterned surfaces and the in vitro biological response of osteoblasts (SAOS-2) towards them were thoroughly analysed. In terms of composition, the laser treatment was found to cause superficial monoclinic-tetragonal zirconia phase transformation and alumina evaporation. In vitro, the most effective grid configuration for osseous differentiation was found to be 1.5 pm groove depth and 10 gm groove separation, and confocal microscopy revealed that the cells show a tendency to be sorted as groove depth increases. It is thought that custom-made patterns could be produced to guide cell attachment in vivo, which could favour implant integration and reduce healing time.
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