期刊
CELLULAR SIGNALLING
卷 41, 期 -, 页码 17-24出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2017.07.004
关键词
Arrestins; GPCR; GRK; Phosphorylation; Signaling; X-ray crystallography
类别
资金
- National Institutes of Health [R01 GM044944, R01 GM047417, R01 HL136219, P01 HL114471]
This review is provided in recognition of the extensive contributions of Dr. Robert J. Lefkowitz to the G protein coupled receptor (GPCR) field and to celebrate his 75th birthday. Since one of the authors trained with Bob in the 80s, we provide a history of work done in the Lefkowitz lab during the 80s that focused on dissecting the mechanisms that regulate GPCR signaling, with a particular emphasis on the GPCR kinases (GRKs). In addition, we highlight structure/function characteristics of GRK interaction with GPCRs as well as a review of two recent reports that provide a molecular model for GRK-GPCR interaction. Finally, we offer our perspective on some future studies that we believe will drive this field.
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