期刊
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
卷 48, 期 1, 页码 251-262出版社
KARGER
DOI: 10.1159/000491724
关键词
Esophageal squamous cell carcinoma (ESCC); LINC01133; IncRNA expression; Prognosis; Alcohol
资金
- Doctoral Scientific Research Foundation of Guangdong Province [2017A030310413]
- China Postdoctoral Science Foundation [2018M633033, 2017M622665]
- Guangzhou Postdoctoral Scientific Research Foundation
- National Natural Science Foundation of China [81372493, 81773301]
- Guangzhou Key Medical Discipline Construction Project Fund
- Clinical Research Promotion Project of Guangzhou Medical University for Building High Level University, Educational Commission of Guangdong Province, China Project [2015KTSCX114]
- Guangzhou Science Technology and Innovation Commission [2014Y2-00548, 2014Y2-00152]
Background/Aims: Considerable evidence indicates that long noncoding RNAs (IncRNAs) exert importantly regulatory functions during human cancer initiation and progression and are promising biotargets in the fight against cancer. Methods: In this study, we evaluated the role of the IncRNA LINC01133 in esophageal squamous cell carcinoma (ESCC). LINC01133 expression in ESCC was examined by quantitative real-time PCR. The correlations between LINC01133 expression and clinicopathological variables and survival were examined by the chi(2) test, Kaplan-Meier method, log-rank test, and univariate Cox regression analysis. Results: LINC01133 expression levels were frequently lower in ESCC tissues and cell lines than in paired normal tissues and an immortalized esophageal epithelial cell line, respectively. The expression of LINC01133 decreased in a TNM stage- and lifestyle-independent manner. LINC01133 was an independent protective factor and had an anti-tumor effect in the early stage of ESCC development. More importantly, we discovered that drinking status in our cohort impaired the predictive accuracy of LINC01133 for patients with ESCC. Furthermore, a new risk model combining LINC01133 expression, drinking status, and TNM stage provided better survival discrimination compared with three other predictors. Conclusions: Our data indicate that a loss of LINC01133 expression is a potential poor prognostic biomarker and therapeutic target for ESCC and provide additional prognostic information to improve the outcomes of ESCC patients. (C) 2018 The Author(s) Published by S. Karger AG, Basel
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