期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 75, 期 17, 页码 3215-3229出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-018-2768-1
关键词
Venom; Saliva; Heteroptera; Belostomatidae; Nepomorpha; Venom evolution; Trophic shift
资金
- University of Queensland Postdoctoral Fellowship Australian National Health and Medical Research Council
- Principal Research Fellowship from the Australian National Health and Medical Research Council
- [MF683255-MF683386]
True Bugs (Insecta: Heteroptera) produce venom or saliva with diverse bioactivities depending on their feeding strategies. However, little is known about the molecular evolution of the venom toxins underlying these biological activities. We examined venom of the giant fish-killing water bug Lethocerus distinctifemur (Insecta: Belostomatidae) using infrared spectroscopy, transcriptomics, and proteomics. We report 132 venom proteins including putative enzymes, cytolytic toxins, and antimicrobial peptides. Over 73% (96 proteins) showed homology to venom proteins from assassin bugs (Reduviidae), including 21% (28 proteins from seven families) not known from other sources. These data suggest that numerous protein families were recruited into venom and diversified rapidly following the switch from phytophagy to predation by ancestral heteropterans, and then were retained over > 200 my of evolution. In contrast, trophic switches to blood-feeding (e.g. in Triatominae and Cimicidae) or reversions to plant-feeding (e.g., in Pentatomomorpha) were accompanied by rapid changes in the composition of venom/saliva, including the loss of many protein families.
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