期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 75, 期 12, 页码 2111-2124出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-018-2787-y
关键词
Rho GTPases; RhoA; RhoB; RhoC; Transcriptional regulation; miRNAs; TGF beta; Signaling cross talks
资金
- Hellenic Ministry for Education, Research and Religious Affairs [THALIS MIS 380334]
- IKY-Siemens Research Grants
Rho GTPases are highly conserved proteins that play critical roles in many cellular processes including actin dynamics, vesicular trafficking, gene transcription, cell-cycle progression, and cell adhesion. The main mode of regulation of Rho GTPases is through guanine nucleotide binding (cycling between an active GTP-bound form and an inactive GDP-bound form), but transcriptional, post-transcriptional, and post-translational modes of Rho regulation have also been described. In the present review, we summarize recent progress on the mechanisms that control the expression of the three members of the Rho-like subfamily (RhoA, RhoB, and RhoC) at the level of gene transcription as well as their post-transcriptional regulation by microRNAs. We also discuss the progress made in deciphering the mechanisms of cross-talk between Rho proteins and the transforming growth factor beta signaling pathway and their implications for the pathogenesis of human diseases such as cancer metastasis and fibrosis.
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