期刊
CELL STEM CELL
卷 22, 期 2, 页码 221-+出版社
CELL PRESS
DOI: 10.1016/j.stem.2018.01.003
关键词
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资金
- Deutsche Forschungsgemeinschaft (German Research Foundation)
- Generalitat Valenciana [PROMETEOII/2014/075]
- NIH Office of the Director (OD)
- National Cancer Institute
- National Institute of Dental and Craniofacial Research (NIDCR) [NIH DP5 OD012194]
- UCSF Center for Systems and Synthetic Biology (NIGMS) [P50 GM081879]
- Chilean government (Becas Chile)
- NIH [NS028478, HD032116]
Somatic stem cells have been identified in multiple adult tissues. Whether self-renewal occurs symmetrically or asymmetrically is key to understanding long-term stem cell maintenance and generation of progeny for cell replacement. In the adult mouse brain, neural stem cells (NSCs) (B1 cells) are retained in the walls of the lateral ventricles (ventricular-subventricular zone [V-SVZ]). The mechanism of B1 cell retention into adulthood for lifelong neurogenesis is unknown. Using multiple clonal labeling techniques, we show that the vast majority of B1 cells divide symmetrically. Whereas 20%-30% symmetrically self-renew and can remain in the niche for several months before generating neurons, 70%-80% undergo consuming divisions generating progeny, resulting in the depletion of B1 cells over time. This cellular mechanism decouples self-renewal from the generation of progeny. Limited rounds of symmetric self-renewal and consuming symmetric differentiation divisions can explain the levels of neurogenesis observed throughout life.
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