期刊
CELL METABOLISM
卷 28, 期 1, 页码 23-+出版社
CELL PRESS
DOI: 10.1016/j.cmet.2018.05.008
关键词
-
资金
- Danish Diabetes Academy - Novo Nordisk Foundation
- Danish Diabetes Academy - Lundbeck Foundation
- Danish Diabetes Academy - Region Zealand Health Scientific Research Foundation
- Danish Diabetes Academy - Aase and Ejnar Danielsens Foundation
- Tripartite Immunometabolism Consortium [TrIC] Novo Nordisk Foundation [NNF15CC0018486]
Pathogenic mutations in the appetite-regulating melanocortin-4 receptor (MC4R) represent the most common cause of monogenic obesity with limited treatment options. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) cause weight loss by reducing appetite. We assessed the effect of the GLP-1 RA liraglutide 3.0 mg for 16 weeks in 14 obese individuals with pathogenic MC4R mutations (BMI 37.5 +/- 6.8) and 28 matched control participants without MC4R mutation (BMI 36.8 +/- 4.8). Liraglutide decreased body weight by 6.8 kg +/- 1.8 kg in individuals with pathogenic MC4R mutations and by 6.1 kg +/- 1.2 kg in control participants. Total body fat, waist circumference, and fasting and postprandial glucose concentrations similarly decreased in both groups. Thus, liraglutide induced an equal, clinically significant weight loss of 6% in both groups, indicating that the appetite-reducing effect of liraglutide is preserved in MC4R causal obesity and that liraglutide acts independently of the MC4R pathway. Thus, liraglutide could be an effective treatment of the most common form of monogenic obesity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据