期刊
CELL METABOLISM
卷 28, 期 1, 页码 175-+出版社
CELL PRESS
DOI: 10.1016/j.cmet.2018.05.002
关键词
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资金
- DFG [SFB914 TP B08, TP B09, TP B01, SFB1123 TP A06, SO876/6-1, SO876/11-1, SCHE 1645/2-1]
- EKFS [2016_A118]
- Vetenskapsradet [2017-01762]
- FoFoLe program of the LMU Munich
- European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie [675111]
- MECI [SEV-2015-0505]
- Pro CNIC Foundation
Onset of cardiovascular complications as a consequence of atherosclerosis exhibits a circadian incidence with a peak in the morning hours. Although development of atherosclerosis extends for long periods of time through arterial leukocyte recruitment, we hypothesized that discrete diurnal invasion of the arterial wall could sustain atherogenic growth. Here, we show that myeloid cell recruitment to atherosclerotic lesions oscillates with a peak during the transition from the activity to the resting phase. This diurnal phenotype is regulated by rhythmic release of myeloid cell-derived CCL2, and blockade of its signaling abolished oscillatory leukocyte adhesion. In contrast, we show that myeloid cell adhesion to microvascular beds peaks during the early activity phase. Consequently, timed pharmacological CCR2 neutralization during the activity phase caused inhibition of atherosclerosis without disturbing microvascular recruitment. These findings demonstrate that chronic inflammation of large vessels feeds on rhythmic myeloid cell recruitment, and lay the foundation for chrono-pharmacology-based therapy.
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