期刊
CELL METABOLISM
卷 27, 期 3, 页码 572-+出版社
CELL PRESS
DOI: 10.1016/j.cmet.2018.01.013
关键词
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资金
- Canadian Institutes of Health Research (CIHR) Foundation [FDN-143204]
- Ontario Graduate Scholarship
- Banting and Best Diabetes Center Graduate Studentship
- Banting and Best Diabetes Center Post-Doctoral Fellowship
- CIHR
- Diabetes Canada post-doctoral fellowship
Long-chain acyl-CoA synthetase (ACSL)-dependent upper small intestinal lipid metabolism activates pre-absorptive pathways to regulate metabolic homeostasis, but whether changes in the upper small intestinal microbiota alter specific fatty acid-dependent pathways to impact glucose homeostasis remains unknown. We here first find that upper small intestinal infusion of Intralipid, oleic acid, or linoleic acid pre-absorptively increases glucose tolerance and lowers glucose production in rodents. High-fat feeding impairs pre-absorptive fatty acid sensing and reduces upper small intestinal Lactobacillus gasseri levels and ACSL3 expression. Transplantation of healthy upper small intestinal microbiota to high-fat-fed rodents restores L. gasseri levels and fatty acid sensing via increased ACSL3 expression, while L. gasseri probiotic administration to non-transplanted high-fat-fed rodents is sufficient to restore upper small intestinal ACSL3 expression and fatty acid sensing. In summary, we unveil a glucoregulatory role of upper small intestinal L. gasseri that impacts an ACSL3-dependent glucoregulatory fatty acid-sensing pathway.
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