期刊
CELL HOST & MICROBE
卷 23, 期 5, 页码 653-+出版社
CELL PRESS
DOI: 10.1016/j.chom.2018.04.009
关键词
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资金
- Australian National Health and Medical Research Council (NHMRC) [APP1098429]
- EMBL Australia Group Leader award
- NHMRC Career Development Fellowship [APP1084951]
Antibody-mediated responses play a critical role in vaccine-mediated immunity. However, for reasons that are poorly understood, these responses are highly variable between individuals. Using a mouse model, we report that antibiotic-driven intestinal dysbiosis, specifically in early life, leads to significantly impaired antibody responses to five different adjuvanted and live vaccines. Restoration of the commensal microbiota following antibiotic exposure rescues these impaired responses. In contrast, antibiotic-treated adult mice do not exhibit impaired antibody responses to vaccination. Interestingly, in contrast to impaired antibody responses, immunized mice exposed to early-life antibiotics display significantly enhanced T cell cytokine recall responses upon ex vivo restimulation with the vaccine antigen. Our results demonstrate that, in mice, antibioticdriven dysregulation of the gut microbiota in early life can modulate immune responses to vaccines that are routinely administered to infants worldwide.
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