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注意:仅列出部分参考文献,下载原文获取全部文献信息。Capicua suppresses hepatocellular carcinoma progression by controlling the ETV4-MMP1 axis
Eunjeong Kim et al.
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Inactivation of Capicua drives cancer metastasis
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A genetic interaction analysis identifies cancer drivers that modify EGFR dependency
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Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma
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GENES & DEVELOPMENT (2017)
Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans
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Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5
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ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition
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A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer
Marta Fores et al.
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Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation
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Hippo Reprograms the Transcriptional Response to Ras Signaling
Justine Pascual et al.
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New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs
Dominik Sturm et al.
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Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia
Koichi Oshima et al.
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Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua
Liu Yang et al.
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CIC inactivating mutations identify aggressive subset of 1p19q codeleted gliomas
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Mutational landscape and clonal architecture in grade II and III gliomas
Hiromichi Suzuki et al.
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Mapping the binding interface of ERK and transcriptional repressor Capicua using photocrosslinking
Alan S. Futran et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Deficiency of Capicua disrupts bile acid homeostasis
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SCIENTIFIC REPORTS (2015)
EGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated Genes
Yinhua Jin et al.
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Origins of Context-Dependent Gene Repression by Capicua
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PLOS GENETICS (2015)
A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1
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A Systematic Ensemble Approach to Thermodynamic Modeling of Gene Expression from Sequence Data
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Next Generation Sequencing in Nonsyndromic Intellectual Disability: From a Negative Molecular Karyotype to a Possible Causative Mutation Detection
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Matthias Drosten et al.
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Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity
Suganthi Chittaranjan et al.
ONCOTARGET (2014)
Structural basis of protein complex formation and reconfiguration by polyglutamine disease protein Ataxin-1 and Capicua
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GENES & DEVELOPMENT (2013)
RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1
Jeehye Park et al.
NATURE (2013)
Riquiqui and Minibrain are regulators of the Hippo pathway downstream of Dachsous
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NATURE CELL BIOLOGY (2013)
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
Patrick J. Killela et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Kinetics of gene derepression by ERK signaling
Bomyi Lim et al.
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Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
Jianjiong Gao et al.
SCIENCE SIGNALING (2013)
Capicua regulates proliferation and survival of RB-deficient cells in Drosophila
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BIOLOGY OPEN (2013)
Mutual Repression by Bantam miRNA and Capicua Links the EGFR/MAPK and Hippo Pathways in Growth Control
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CURRENT BIOLOGY (2012)
Torso RTK controls Capicua degradation by changing its subcellular localization
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DEVELOPMENT (2012)
The Capicua repressor - a general sensor of RTK signaling in development and disease
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JOURNAL OF CELL SCIENCE (2012)
Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers
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JOURNAL OF PATHOLOGY (2012)
The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data
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CANCER DISCOVERY (2012)
ERK/p90RSK/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicua
Kumara Dissanayake et al.
BIOCHEMICAL JOURNAL (2011)
Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
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CANCER CELL (2011)
Capicua DNA-binding sites are general response elements for RTK signaling in Drosophila
Leiore Ajuria et al.
DEVELOPMENT (2011)
Cooperative Regulation of Growth by Yorkie and Mad through bantam
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DEVELOPMENTAL CELL (2011)
ATXN1 Protein Family and CIC Regulate Extracellular Matrix Remodeling and Lung Alveolarization
Yoontae Lee et al.
DEVELOPMENTAL CELL (2011)
Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma
Chetan Bettegowda et al.
SCIENCE (2011)
Exercise and Genetic Rescue of SCA1 via the Transcriptional Repressor Capicua
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SCIENCE (2011)
Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival
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EMBO JOURNAL (2010)
A de novo paradigm for mental retardation
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Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents
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Partial Loss of Ataxin-1 Function Contributes to Transcriptional Dysregulation in Spinocerebellar Ataxia Type 1 Pathogenesis
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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
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Antagonistic action of Bicoid and the repressor Capicua determines the spatial limits of Drosophila head gene expression domains
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The zinc-finger protein Zelda is a key activator of the early zygotic genome in Drosophila
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Capicua regulates cell proliferation downstream of the receptor tyrosine kinase/Ras signaling pathway
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CURRENT BIOLOGY (2007)
A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling
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EMBO JOURNAL (2007)
ATAXIN-1 interacts with the repressor capicua in its native complex to cause SCA1 neuropathology
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The bantam microRNA is a target of the hippo tumor-suppressor pathway
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The hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila
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Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation
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Boat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1
A Mizutani et al.
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Leukemia-related transcription factor TEL is negatively regulated through extracellular signal-regulated kinase-induced phosphorylation
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Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors
CC Tsai et al.
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CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons
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