期刊
CELL CALCIUM
卷 74, 期 -, 页码 53-60出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2018.06.004
关键词
Synapse; Vesicle pools; Synaptotagmin; Exocytosis; Synaptic transmission
类别
资金
- Spanish Ministry of Economy and Competitiveness [BFU2015-64536-R]
- Junta de Andalucia [BIO-209]
Continuous neurotransmitter release is subjected to synaptic vesicle availability, which in turn depends on vesicle recycling and the traffic of vesicles between pools. We studied the role of Synaptotagmin-7 (Syt-7) in synaptic vesicle accessibility for release in hippocampal neurons in culture. Synaptic boutons from Syt-7 knockout (KO) mice displayed normal basal secretion with no alteration in the RRP size or the probability of release. However, stronger stimuli revealed an increase in the size of the reserve and resting vesicle pools in Syt7 KO boutons compared with WT. These data suggest that Syt-7 plays a significant role in the vesicle pool homeostasis and, consequently, in the availability of vesicles for synaptic transmission during strong stimulation, probably, by facilitating advancing synaptic vesicles to the readily releasable pool.
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