相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Neurodegeneration and the ordered assembly of α-synuclein
Maria Grazia Spillantini et al.
CELL AND TISSUE RESEARCH (2018)
α-Synuclein-carrying extracellular vesicles in Parkinson's disease: deadly transmitters
Dimitry A. Chistiakov et al.
ACTA NEUROLOGICA BELGICA (2017)
Brain-to-stomach transfer of α-synuclein via vagal preganglionic projections
Ayse Ulusoy et al.
ACTA NEUROPATHOLOGICA (2017)
Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration
Michel Goedert et al.
BRAIN (2017)
Potential Modes of Intercellular -Synuclein Transmission
Dario Valdinocci et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
'Prion-like' propagation of the synucleinopathy of M83 transgenic mice depends on the mouse genotype and type of inoculum
Dorian Sargent et al.
JOURNAL OF NEUROCHEMISTRY (2017)
Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes
Jinar Rostami et al.
JOURNAL OF NEUROSCIENCE (2017)
Parkinson's Disease Is Not Simply a Prion Disorder
James Surmeier et al.
JOURNAL OF NEUROSCIENCE (2017)
Prying into the Prion Hypothesis for Parkinson's Disease
Patrik Brundin et al.
JOURNAL OF NEUROSCIENCE (2017)
The prion model for progression and diversity of neurodegenerative diseases
Barbara E. Stopschinski et al.
LANCET NEUROLOGY (2017)
Solving the conundrum of insoluble protein aggregates
Sonia George et al.
LANCET NEUROLOGY (2017)
Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage
Veronica Lindstrom et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2017)
Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice
Emily J. Koller et al.
MOLECULAR NEURODEGENERATION (2017)
Aging and Parkinson's Disease: Different Sides of the Same Coin?
Timothy J. Collier et al.
MOVEMENT DISORDERS (2017)
α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies
Yvette C. Wong et al.
NATURE MEDICINE (2017)
α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration
Hisham Abdelmotilib et al.
NEUROBIOLOGY OF DISEASE (2017)
Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions
Amulya Nidhi Shrivastava et al.
NEURON (2017)
Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders
Masato Hasegawa et al.
PHARMACOLOGY & THERAPEUTICS (2017)
Modeling Parkinson's disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain
Poonam Thakur et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy
Brian Spencer et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2017)
Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein
Trevor Tyson et al.
SCIENTIFIC REPORTS (2017)
Like prions: the propagation of aggregated tau and alpha-synuclein in neurodegeneration
Michel Goedert et al.
BRAIN (2017)
α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading
Frida Loria et al.
ACTA NEUROPATHOLOGICA (2017)
Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins
William P. Flavin et al.
ACTA NEUROPATHOLOGICA (2017)
Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production
Victor Tapias et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2017)
Brain propagation of transduced α-synuclein involves non-fibrillar protein species and is enhanced in α-synuclein null mice
Michael Helwig et al.
BRAIN (2016)
Alpha-synuclein propagation: New insights from animal models
Benjamin Dehay et al.
MOVEMENT DISORDERS (2016)
Proteopathic Strains and the Heterogeneity of Neurodegenerative Diseases
Lary C. Walker
ANNUAL REVIEW OF GENETICS, VOL 50 (2016)
Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease
Nolwen L. Rey et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2016)
?-Synuclein strains and the variable pathologies of synucleinopathies
Wouter Peelaerts et al.
JOURNAL OF NEUROCHEMISTRY (2016)
Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance
Dena G. Hernandez et al.
JOURNAL OF NEUROCHEMISTRY (2016)
Neuroinvasion of α-Synuclein Prionoids after Intraperitoneal and Intraglossal Inoculation
Sara Breid et al.
JOURNAL OF VIROLOGY (2016)
Transfer of mitochondria from astrocytes to neurons after stroke
Kazuhide Hayakawa et al.
NATURE (2016)
Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein
N. L. Rey et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2016)
Review: Parkinson's disease: from synaptic loss to connectome dysfunction
Arianna Bellucci et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2016)
Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3
Xiaobo Mao et al.
SCIENCE (2016)
α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease
Roberto Di Maio et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
α-synuclein assemblies sequester neuronal α3-Na+/K+-ATPase and impair Na+ gradient
Amulya Nidhi Shrivastava et al.
EMBO JOURNAL (2015)
A53T Human α-Synuclein Overexpression in Transgenic Mice Induces Pervasive Mitochondria Macroautophagy Defects Preceding Dopamine Neuron Degeneration
Linan Chen et al.
JOURNAL OF NEUROSCIENCE (2015)
α-Synuclein strains cause distinct synucleinopathies after local and systemic administration
W. Peelaerts et al.
NATURE (2015)
Depletion of microglia and inhibition of exosome synthesis halt tau propagation
Hirohide Asai et al.
NATURE NEUROSCIENCE (2015)
Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration
Katrina L. Paumier et al.
NEUROBIOLOGY OF DISEASE (2015)
Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice
Eve Peeraer et al.
NEUROBIOLOGY OF DISEASE (2015)
Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism
Stanley B. Prusiner et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons
A. K. Reeve et al.
CELL DEATH & DISEASE (2015)
Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism
Valerie R. Osterberg et al.
CELL REPORTS (2015)
Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury
Ayse Ulusoy et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2015)
Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein
Maria E. Bernis et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2015)
Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats
Staffan Holmqvist et al.
ACTA NEUROPATHOLOGICA (2014)
Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice
Amanda N. Sacino et al.
ACTA NEUROPATHOLOGICA (2014)
Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys
Ariadna Recasens et al.
ANNALS OF NEUROLOGY (2014)
Alpha-Synuclein Transfers from Neurons to Oligodendrocytes
Juan F. Reyes et al.
GLIA (2014)
Stage-Dependent Nigral Neuronal Loss in Incidental Lewy Body and Parkinson's Disease
Anke A. Dijkstra et al.
MOVEMENT DISORDERS (2014)
Extracellular α-synuclein-a novel and crucial factor in Lewy body diseases
He-Jin Lee et al.
NATURE REVIEWS NEUROLOGY (2014)
Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice
Amanda N. Sacino et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Organization of Monosynaptic Inputs to the Serotonin and Dopamine Neuromodulatory Systems
Sachie K. Ogawa et al.
CELL REPORTS (2014)
Pathological alpha-synuclein propagates through neural networks
Masami Masuda-Suzukake et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2014)
Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice
Nolwen L. Rey et al.
ACTA NEUROPATHOLOGICA (2013)
Prion-like spreading of pathological α-synuclein in brain
Masami Masuda-Suzukake et al.
BRAIN (2013)
Caudo-rostral brain spreading of α-synuclein through vagal connections
Ayse Ulusoy et al.
EMBO MOLECULAR MEDICINE (2013)
Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease?
S. J. Chinta et al.
JOURNAL OF INTERNAL MEDICINE (2013)
α-Synuclein Oligomers: an Amyloid Pore?
Martin T. Stckl et al.
MOLECULAR NEUROBIOLOGY (2013)
The many faces of alpha-synuclein: from structure and toxicity to therapeutic target
Hilal A. Lashuel et al.
NATURE REVIEWS NEUROSCIENCE (2013)
Exosomes of BV-2 cells induced by alpha-synuclein: Important mediator of neurodegeneration in PD
Chongwang Chang et al.
NEUROSCIENCE LETTERS (2013)
Transmission of multiple system atrophy prions to transgenic mice
Joel C. Watts et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Extracellular vesicles as mediators of neuron-glia communication
Carsten Fruehbeis et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2013)
Induction of CNS alpha-synuclein pathology by fibrillar and non- amyloidogenic recombinant alpha-synuclein
Amanda N. Sacino et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2013)
γ-Synuclein: Seeding of α-Synuclein Aggregation and Transmission between Cells
Irina Surgucheva et al.
BIOCHEMISTRY (2012)
Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation
Igor F. Tsigelny et al.
FEBS JOURNAL (2012)
Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease
Margaux F. Keller et al.
HUMAN MOLECULAR GENETICS (2012)
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
Kelvin C. Luk et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Exosomal cell-to-cell transmission of alpha synuclein oligomers
Karin M. Danzer et al.
MOLECULAR NEURODEGENERATION (2012)
Prion-like acceleration of a synucleinopathy in a transgenic mouse model
Anne-Laure Mougenot et al.
NEUROBIOLOGY OF AGING (2012)
Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease
Joshua M. Milber et al.
NEUROLOGY (2012)
Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
Alix de Calignon et al.
NEURON (2012)
Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons
Mitsuko Watabe-Uchida et al.
NEURON (2012)
Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo
Elodie Angot et al.
PLOS ONE (2012)
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
Kelvin C. Luk et al.
SCIENCE (2012)
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
Christian Hansen et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat
Jeffrey H. Kordower et al.
NEUROBIOLOGY OF DISEASE (2011)
Clinical Progression in Parkinson Disease and the Neurobiology of Axons
Hsiao-Chun Cheng et al.
ANNALS OF NEUROLOGY (2010)
Molecular inflammation: Underpinnings of aging and age-related diseases
Hae Young Chung et al.
AGEING RESEARCH REVIEWS (2009)
Parkinson's Disease The Dual Hit Theory Revisited
Christopher H. Hawkes et al.
INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE (2009)
Structural insights on physiological functions and pathological effects of α-synuclein
Marco Bisaglia et al.
FASEB JOURNAL (2009)
Formation and development of Lewy pathology: a critical update
Kurt A. Jellinger
JOURNAL OF NEUROLOGY (2009)
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein
Paula Desplats et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Mitochondrial association of alpha-synuclein causes oxidative stress
M. S. Parihar et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
Jia-Yi Li et al.
NATURE MEDICINE (2008)
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
Jeffrey H. Kordower et al.
NATURE MEDICINE (2008)
Research in motion: the enigma of Parkinson's disease pathology spread
Patrik Brundin et al.
NATURE REVIEWS NEUROSCIENCE (2008)
Hypocretin (orexin) loss and sleep disturbances in Parkinsons Disease
Rolf Fronczek et al.
BRAIN (2008)
Parkinson's disease: a dual-hit hypothesis
C. H. Hawkes et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2007)
Hypocretin (orexin) cell loss in Parkinson's disease
Thomas C. Thannickal et al.
BRAIN (2007)
Aggregated α-synuclein mediates dopaminergic neurotoxicity in vivo
Magali Periquet et al.
JOURNAL OF NEUROSCIENCE (2007)
Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain
Andisheh Eslamboli et al.
BRAIN (2007)
Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans
Claudio Franceschi et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2007)
α-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity
Eirene Kontopoulos et al.
HUMAN MOLECULAR GENETICS (2006)
Selective loss of dopaminergic neurons and formation of Lewy body-like aggregations in α-synuclein transgenic fly neuronal cultures
Soon S. Park et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2006)
Mutant α-synuclein-induced degeneration is reduced by parkin in a fly model of Parkinson's disease
Annika F. M. Haywood et al.
GENOME (2006)
Familial Parkinson mutant α-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans
T Kuwahara et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Parkinson's disease α-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death
LJ Martin et al.
JOURNAL OF NEUROSCIENCE (2006)
Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity
WW Smith et al.
HUMAN MOLECULAR GENETICS (2005)
Expression of normal sequence pathogenic proteins for neurodegenerative disease contributes to disease risk: 'permissive templating' as a general mechanism underlying neurodegeneration
J Hardy
BIOCHEMICAL SOCIETY TRANSACTIONS (2005)
Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway
R Cappai et al.
FASEB JOURNAL (2005)
α-Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease
L Chen et al.
NATURE NEUROSCIENCE (2005)
No global loss of neocortical neurons in Parkinson's disease: A quantitative stereological study
KM Pedersen et al.
MOVEMENT DISORDERS (2005)
Proteasomal inhibition by α-synuclein filaments and oligomers
E Lindersson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy
AM Cuervo et al.
SCIENCE (2004)
Overexpression of α-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of α-synuclein and activation of caspase-9:: resemblance to pathogenetic changes in Parkinson's disease
M Yamada et al.
JOURNAL OF NEUROCHEMISTRY (2004)
α-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma
OMA El-Agnaf et al.
FASEB JOURNAL (2003)
Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human α-synuclein
M Lakso et al.
JOURNAL OF NEUROCHEMISTRY (2003)
Idiopathic Parkinson's disease:: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen
H Braak et al.
JOURNAL OF NEURAL TRANSMISSION (2003)
Nigrostriatal α-synucleinopathy induced by viral vector-mediated overexpression of human α-synuclein:: A new primate model of Parkinson's disease
D Kirik et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Staging of brain pathology related to sporadic Parkinson's disease
H Braak et al.
NEUROBIOLOGY OF AGING (2003)
Parkin protects against the toxicity associated with mutant α-synuclein:: Proteasome dysfunction selectively affects catecholaminergic neurons
L Petrucelli et al.
NEURON (2002)
Selective loss of pyramidal neurons in the pre-supplementary motor cortex in Parkinson's disease
V MacDonald et al.
MOVEMENT DISORDERS (2002)
Clinical correlates of selective pathology in the amygdala of patients with Parkinson's disease
AJ Harding et al.
BRAIN (2002)
α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease
C Lo Bianco et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53→Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice
MK Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Neuronal α-synucleinopathy with severe movement disorder in mice expressing A53T human α-synuclein
BI Giasson et al.
NEURON (2002)
Behavioral and neurochemical effects of wild-type and mutated human α-synuclein in transgenic mice
EK Richfield et al.
EXPERIMENTAL NEUROLOGY (2002)
Parkinson-like neurodegeneration induced by targeted overexpression of α-synuclein in the nigrostriatal system
D Kirik et al.
JOURNAL OF NEUROSCIENCE (2002)
Expression of A53T mutant but not wild-type α-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death
L Stefanis et al.
JOURNAL OF NEUROSCIENCE (2001)
Lack of nigral pathology in transgenic mice expressing human α-synuclein driven by the tyrosine hydroxylase promoter
Y Matsuoka et al.
NEUROBIOLOGY OF DISEASE (2001)
Inducible expression of mutant α-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis
Y Tanaka et al.
HUMAN MOLECULAR GENETICS (2001)
Neuropathology in mice expressing human α-synuclein
H van der Putten et al.
JOURNAL OF NEUROSCIENCE (2000)
Dopaminergic loss and inclusion body formation in α-synuclein mice:: Implications for neurodegenerative disorders
E Masliah et al.
SCIENCE (2000)
Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha-synuclein in human and transgenic mouse brain
PJ Kahle et al.
JOURNAL OF NEUROSCIENCE (2000)
分享论文
