期刊
CELL
卷 173, 期 1, 页码 248-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2018.02.028
关键词
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资金
- Chinese Academy of Sciences [XDB13040200]
- National Key RD Program [2015CB856200]
- National Natural Science Foundation of China [91731312, 31425015, 31601052, 31561130152, 81601256]
- CAS [QYZDY-SSW-SMC016]
The dynamics of the chromatin regulatory landscape during human early embryogenesis remains unknown. Using DNase I hypersensitive site (DHS) sequencing, we report that the chromatin accessibility landscape is gradually established during human early embryogenesis. Interestingly, the DHSs with OCT4 binding motifs are enriched at the timing of zygotic genome activation (ZGA) in humans, but not in mice. Consistently, OCT4 contributes to ZGA in humans, but not in mice. We further find that lower CpG promoters usually establish DHSs at later stages. Similarly, younger genes tend to establish promoter DHSs and are expressed at later embryonic stages, while older genes exhibit these features at earlier stages. Moreover, our data show that human active transposons SVA and HERV-K harbor DHSs and are highly expressed in early embryos, but not in differentiated tissues. In summary, our data provide an evolutionary developmental view for understanding the regulation of gene and transposon expression.
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