期刊
CELL
卷 173, 期 1, 页码 153-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2018.02.004
关键词
-
资金
- Science for Life Laboratory
- Knut and Alice Wallenberg Foundation
- Karolinska Institutet
- National Genomics Infrastructure - Swedish Research Council
- Foundation for Science and Technology from the Portuguese government [SFRH/BD/63164/2009]
- European Union's Seventh Framework Programme [310938 PERICYTESCAR]
- Swedish Research Council
- SFO StratRegen
- Hjarnfonden
- Ming Wai Lau Centre
- Swedish Cancer Foundation
- JPND DACAPO-AD
- Wings for Life Foundation
- Tobias Stiftelsen
- SSF
- Torsten Soderberg Foundation
- Knut och Alice Wallenbergs Stiftelse
- Fundação para a Ciência e a Tecnologia [SFRH/BD/63164/2009] Funding Source: FCT
CNS injury often severs axons. Scar tissue that forms locally at the lesion site is thought to block axonal regeneration, resulting in permanent functional deficits. We report that inhibiting the generation of progeny by a subclass of pericytes led to decreased fibrosis and extracellular matrix deposition after spinal cord injury in mice. Regeneration of raphespinal and corticospinal tract axons was enhanced and sensorimotor function recovery improved following spinal cord injury in animals with attenuated pericyte-derived scarring. Using optogenetic stimulation, we demonstrate that regenerated corticospinal tract axons integrated into the local spinal cord circuitry below the lesion site. The number of regenerated axons correlated with improved sensorimotor function recovery. In conclusion, attenuation of pericyte-derived fibrosis represents a promising therapeutic approach to facilitate recovery following CNS injury.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据