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New models to study vascular mural cell embryonic origin: implications in vascular diseases

期刊

CARDIOVASCULAR RESEARCH
卷 114, 期 4, 页码 481-491

出版社

OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvy005

关键词

Smooth muscle cell; Pericyte; Embryonic orgin; Vascular

资金

  1. ERC-Consolidator Grant Rendox [647057]
  2. AIRC grant [IG 20119]
  3. British Heart Foundation [FS/13/29/30024]
  4. British Heart Foundation [FS/18/46/33663] Funding Source: researchfish
  5. Medical Research Council [MC_PC_12009] Funding Source: researchfish

向作者/读者索取更多资源

A key question in vascular biology is how the diversity of origin of vascular mural cells, namely smooth muscle cells (SMCs) and pericytes influences vessel properties, in particular the regional propensity to vascular diseases. This review therefore first describes the role and regulation of mural cells during vascular formation, with a focus on embryonic origin. We then consider the evidence that connects heterogeneities in SMC and pericyte origins with disease. Since this idea has major implications for understanding and modelling human disease, then there is a pressing need for new model systems to investigate mural cell development and the consequences of heterogeneity. Recent advances arising from in vitro strategies for deriving mural cells from human pluripotent stem cells as well as from the zebrafish model will be discussed and the medical relevance of these discoveries will be highlighted.

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