期刊
CARDIOVASCULAR DIABETOLOGY
卷 17, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12933-018-0738-4
关键词
Type 2 diabetes; Metformin; Atorvastatin; Simvastatin; Combination therapy; Dyslipidemia; Glucose metabolism; Lipid metabolism
资金
- European Union Grant FP7-HEALTH [305707]
Patients with diabetes type 2 have an increased risk for cardiovascular disease and commonly use combination therapy consisting of the anti-diabetic drug metformin and a cholesterol-lowering statin. However, both drugs act on glucose and lipid metabolism which could lead to adverse effects when used in combination as compared to monotherapy. In this review, the proposed molecular mechanisms of action of statin and metformin therapy in patients with diabetes and dyslipidemia are critically assessed, and a hypothesis for mechanisms underlying interactions between these drugs in combination therapy is developed.
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