期刊
CARDIOLOGY CLINICS
卷 36, 期 2, 页码 193-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccl.2017.10.001
关键词
LDL; HDL; Dyslipidemia; CETP; Monocyte-derived macrophage
Apolipoprotein B-containing lipoproteins and low-density lipoprotein play a key role in atherosclerotic vascular disease. Modified forms of low-density lipoprotein drive inflammation, an integral aspect of plaque progression. High-density lipoprotein particles are equipped to protect low-density lipoprotein from enzymatic and nonenzymatic modification. Under normal conditions, high-density lipoproteins facilitate cholesterol efflux from tissues, preventing its accumulation with deleterious consequences. However, the high-density lipoprotein particles characteristic of dyslipidemic states associated with premature atherosclerosis are typically dysfunctional as a result of alteration in their metabolism and consequently their structure and composition. Such an effect indirectly enhances low-density lipoprotein atherogenicity.
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